Sex Differences in Pediatric Infectious Diseases

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Sex Differences in Pediatric Infectious Diseases

The success of the immune response is finely balanced between, on the one hand, the need to engage vigorously with, and clear, certain pathogens; and, on the other, the requirement to minimize immunopathology and autoimmunity. Distinct immune strategies to achieve this balance have evolved in females and males and also in infancy through to adulthood. Sex differences in outcome from a range of ...

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Demographic Evidence of Sex Differences in Vulnerability to Infectious Diseases

TO THE EDITOR—The journal's recent supplement on sex differences in susceptibility and response to infectious diseases was an excellent initiative for promoting research on a neglected topic of major interest [1–8]. If, in general, males show a higher susceptibility to many infectious diseases, the reviews displayed a number of infectious and autoimmune diseases for which females are more vulne...

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Sex differences shape the response to infectious diseases

Historically, we have overlooked sex as a variable in infectious disease research [1, 2]. For example, while much of our knowledge comes from animal studies, many researchers routinely use only male animals [3]. One of the principal reasons for this is the argument that female animals, undergoing cyclic hormonal fluctuations, introduce additional experimental variation [4]. Sex bias is also a m...

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Comparative Effectiveness Research in Pediatric Infectious Diseases.

Comparative-effectiveness research (CER) is a hot topic. There are several definitions for CER, but the Institute ofMedicine defines CER as “the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat andmonitor a clinical condition or to improve the delivery of care” [1]. Comparative-effectiveness research focuses more on eff...

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Curbside Consultations in Pediatric Infectious Diseases.

The Pediatric ID Consultant section provides brief reviews of topics relevant to the day-to-day practice of pediatric infectious diseases. The reviews are placed in context by a short vignette, followed by one or more questions which are addressed. Pediatric infectious diseases physicians are often asked by medical colleagues to provide recommendations for management of a patient without the be...

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ژورنال

عنوان ژورنال: Journal of Infectious Diseases

سال: 2014

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/jiu232